Subclinical hypothyroidism, dyslipidaemia, diabetes and vitamin D status in Nepalese patients with ischemic and haemorrhagic stroke

Abstract

Introduction: Subclinical hypothyroidism (SCH), dyslipidaemia, diabetes and vitamin D are known to be associated with adverse cardiovascular events, including stroke. We aimed to explore the differences in SCH, dyslipidaemia, diabetes and vitamin D among stroke types.

Materials and methods: A cross–sectional study was conducted from January 2015 to December 2017 at Neuro and Allied Clinic, Bhairahawa, Nepal. Seventy–five stroke patients diagnosed by a Neurologist were evaluated for conventional risk factors, levels of thyroid function test, lipid profile, random blood sugar, HbA1C and vitamin D. Descriptive statistics were obtained and differences in SCH, dyslipidaemia, diabetes and vitamin D between stroke types were determined Mann–Whitney U test.

Results: The median(IQR) age was 57(20) years and 69.9% (n=58) were male. Sixty three out of 75 stroke patients were ischemic. The difference in the median (IQR) of laboratory findings between ischemic and haemorrhagic stroke was 4(3) µlU/ml and 3(4.5) µlU/ml for TSH, 1(1) pg/ml and 1(1) pg/ml for T3, 7(3) µg/dl and 7.5(3) µg/dl for T4, 169(32) mg/dL and 165(30) mg/dL for total cholesterol, 104(28) mg/dL and 107.5(28.5) mg/dL for LDL, 138(55) mg/dL and 137.5(57) mg/dL for TG, 38(1) mg/dL and 37(1) mg/dL for HDL, 120(30) mg/dL and 123.5(31) mg/dL for RBS, 26(7) ng/mL and 29(9.75) ng/mL for vitamin D. However, there was no statistically significant difference in all the parameters across the types of stroke.

Conclusion: Our study suggests that there is no significant differences in SCH, dyslipidaemia, diabetes and vitamin D among stroke types.